Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 4/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 4/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | GGT1 | P19440 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.32 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | PYGL | P06737 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29213395 | 1.00 | GRN (0.40) | GRNSORT1NAMPTHPGDSP2RX7 | |
| SCHEMBL30903304 | 1.00 | GRN (0.40) | GRNSORT1NAMPTHPGDSP2RX7 | |
| Hydrochloric Acid SCHEMBL29213409 | 0.99 | GRN (0.39) | GRNSORT1NAMPTHPGDSP2RX7 | |
| Hydrochloric Acid SCHEMBL29213413 | 0.99 | GRN (0.39) | GRNSORT1NAMPTHPGDSP2RX7 | |
| Hydrochloric Acid SCHEMBL30903354 | 0.99 | GRN (0.39) | GRNSORT1NAMPTHPGDSP2RX7 | |
| SCHEMBL29213283 | 0.81 | RAB9A (0.44) | GRNSORT1KDM4E | |
| SCHEMBL29213280 | 0.81 | RAB9A (0.44) | GRNSORT1KDM4E | |
| SCHEMBL31052893 | 0.79 | ITGAV (0.44) | GRNSORT1P2RX7KDM4EITGAV | |
| SCHEMBL29213372 | 0.76 | KDM4E (0.39) | GRNSORT1GGT1KDM4EPYGL | |
| SCHEMBL29213369 | 0.76 | KDM4E (0.39) | GRNSORT1GGT1KDM4EPYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | claimed |
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | disclosed |