Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 4/20 | 0.52 |
| ▸ | SORT1 | Q99523 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29213436 | 1.00 | GRN (0.52) | GRNSORT1ALDH1A1LMNATSHR | |
| SCHEMBL30903308 | 0.87 | GRN (0.46) | GRNSORT1LMNAGAA | |
| SCHEMBL29213334 | 0.86 | GRN (0.63) | GRNSORT1ACE | |
| SCHEMBL29213330 | 0.86 | GRN (0.63) | GRNSORT1ACE | |
| Hydrochloric Acid SCHEMBL30219109 | 0.85 | GRN (0.45) | GRNSORT1LMNAGAA | |
| SCHEMBL30903301 | 0.85 | GRN (0.49) | GRNSORT1TSHRMEN1KMT2A | |
| SCHEMBL29213275 | 0.85 | GRN (0.49) | GRNSORT1TSHRMEN1KMT2A | |
| SCHEMBL29213278 | 0.85 | GRN (0.49) | GRNSORT1TSHRMEN1KMT2A | |
| SCHEMBL29213290 | 0.83 | LDHA (0.48) | PPARGPPARAMEN1KMT2AACE | |
| SCHEMBL29213287 | 0.83 | LDHA (0.48) | PPARGPPARAMEN1KMT2AACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | claimed |
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | disclosed |