Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.66 |
| ▸ | HTT | P42858 | 4/20 | 0.66 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.66 |
| ▸ | MMP2 | P08253 | 1/20 | 0.66 |
| ▸ | RAD52 | P43351 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30869236 | 1.00 | MAPT (0.66) | MAPTSMN1; SMN2ALDH1A1HTTPSMD14 | |
| SCHEMBL29214853 | 1.00 | MAPT (0.66) | MAPTSMN1; SMN2ALDH1A1HTTPSMD14 | |
| SCHEMBL29214805 | 0.89 | MAPT (0.72) | MAPTSMN1; SMN2ALDH1A1HTTPSMD14 | |
| SCHEMBL30869250 | 0.89 | MAPT (0.72) | MAPTSMN1; SMN2ALDH1A1HTTPSMD14 | |
| SCHEMBL29214809 | 0.89 | MAPT (0.72) | MAPTSMN1; SMN2ALDH1A1HTTPSMD14 | |
| SCHEMBL29214732 | 0.87 | ALDH1A1 (0.64) | MAPTSMN1; SMN2ALDH1A1MMP2KMT2A | |
| SCHEMBL29214736 | 0.87 | ALDH1A1 (0.64) | MAPTSMN1; SMN2ALDH1A1MMP2KMT2A | |
| SCHEMBL29214749 | 0.81 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1MMP2KMT2APOLB | |
| SCHEMBL14560452 | 0.80 | MAPT (0.66) | MAPTSMN1; SMN2ALDH1A1HTTPSMD14 | |
| SCHEMBL29214969 | 0.79 | HDAC1 (0.67) | MAPTSMN1; SMN2ALDH1A1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117777049-B | Thiazolidinedione HDAC inhibitor, preparation method and application | 南京市鸿舜医药科技有限公司 | 2024-05-31 | — | — | CN | claimed |
| CN-117777049-A | Thiazolidinedione HDAC inhibitor, preparation method and application | 南京市鸿舜医药科技有限公司 | 2024-03-29 | — | — | CN | claimed |
| CN-117777049-B | Thiazolidinedione HDAC inhibitor, preparation method and application | 南京市鸿舜医药科技有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-117777049-A | Thiazolidinedione HDAC inhibitor, preparation method and application | 南京市鸿舜医药科技有限公司 | 2024-03-29 | — | — | CN | disclosed |