Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | FES | P07332 | 2/20 | 0.43 |
| ▸ | MARK3 | P27448 | 2/20 | 0.43 |
| ▸ | FLT4 | P35916 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.43 |
| ▸ | NEK4 | P51957 | 2/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.43 |
| ▸ | STK3 | Q13188 | 2/20 | 0.43 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.43 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24955708 | 1.00 | DYRK1A (0.43) | DYRK1AROCK2PRKD3MAP4K4CDK1 | |
| SCHEMBL24954316 | 0.84 | MAP4K1 (0.43) | SYKCDK2ITKMAP4K1CAMKK2 | |
| SCHEMBL29216555 | 0.84 | MAP4K1 (0.43) | SYKCDK2ITKMAP4K1CAMKK2 | |
| SCHEMBL22922551 | 0.84 | MAP4K1 (0.53) | DYRK1AROCK2PRKD3MAP4K4CDK1 | |
| SCHEMBL22922550 | 0.84 | MAP4K1 (0.53) | DYRK1AROCK2PRKD3MAP4K4CDK1 | |
| SCHEMBL22922400 | 0.78 | DYRK1A (0.60) | DYRK1AROCK2PRKD3MAP4K4CDK1 | |
| SCHEMBL22859165 | 0.78 | POLB (0.37) | — | |
| SCHEMBL28502196 | 0.78 | POLB (0.37) | — | |
| SCHEMBL22858979 | 0.78 | POLB (0.37) | — | |
| SCHEMBL24954352 | 0.76 | MAP4K1 (0.51) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118043324-A | Pyrrolo [2,3-b ] pyrazine-based bifunctional compounds as HPK1 degradants and uses thereof | 百济神州有限公司 | 2024-05-14 | — | — | CN | disclosed |