Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30215949 | 1.00 | MAP4K1 (0.51) | MAP4K1PIK3CG | |
| SCHEMBL24954419 | 0.89 | MAP4K1 (0.58) | MAP4K1 | |
| SCHEMBL30215935 | 0.89 | MAP4K1 (0.58) | MAP4K1 | |
| SCHEMBL24954375 | 0.81 | MAP4K1 (0.59) | MAP4K1PIK3CG | |
| SCHEMBL24954376 | 0.81 | MAP4K1 (0.59) | MAP4K1PIK3CG | |
| SCHEMBL24954501 | 0.77 | MAP4K1 (0.51) | MAP4K1PIK3CG | |
| SCHEMBL24955736 | 0.76 | MAP4K1 (0.63) | MAP4K1PIK3CG | |
| SCHEMBL24955735 | 0.76 | MAP4K1 (0.63) | MAP4K1PIK3CG | |
| SCHEMBL24955708 | 0.76 | DYRK1A (0.43) | MAP4K1 | |
| SCHEMBL29216538 | 0.76 | DYRK1A (0.43) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006063-A1 | PYRROLO [2, 3-b] PYRAZINE-BASED BIFUNCTIONAL COMPOUNDS AS HPK1 DEGRADERS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-02-02 | — | — | WO | disclosed |