Mesulergine

Mesulergine

SCHEMBL292175

CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2B P41595 6/20 1.00
HTR2A P28223 4/20 1.00
ALDH1A1 P00352 4/20 1.00
HTR7 P34969 3/20 1.00
HTR1A P08908 3/20 1.00
HTR2C P28335 3/20 1.00
HTR6 P50406 2/20 1.00
CYP2D6 P10635 6/20 0.66
RGS12 O14924 3/20 0.66
GNAI1 P63096 3/20 0.66
CYP1A2 P05177 2/20 0.66
LMNA P02545 4/20 0.65
KDM4E B2RXH2 3/20 0.65
PMP22 Q01453 3/20 0.65
DRD2 P14416 3/20 0.50
MEN1 O00255 5/20 0.49
KMT2A Q03164 5/20 0.49
CYP3A4 P08684 4/20 0.49
TSHR P16473 3/20 0.49
TDP1 Q9NUW8 3/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mesulergine SCHEMBL11415354 1.00 HTR2B (1.00) HTR2BHTR2AALDH1A1HTR7HTR1A
Mesulergine SCHEMBL3143855 1.00 HTR2B (1.00) HTR2BHTR2AALDH1A1HTR7HTR1A
Mesulergine SCHEMBL29408582 1.00 HTR2B (1.00) HTR2BHTR2AALDH1A1HTR7HTR1A
Mesulergine SCHEMBL1321023 0.99 HTR2B (0.98) HTR2BHTR2AALDH1A1HTR7HTR1A
Mesulergine SCHEMBL677489 0.98 HTR2B (0.96) HTR2BHTR2AALDH1A1HTR7HTR1A
SCHEMBL10670412 0.88 HTR2B (0.78) HTR2BHTR2AALDH1A1HTR7HTR1A
SCHEMBL10670405 0.88 HTR2B (0.78) HTR2BHTR2AALDH1A1HTR7HTR1A
SCHEMBL10670418 0.88 HTR2B (0.78) HTR2BHTR2AALDH1A1HTR7HTR1A
Disulergine SCHEMBL11408974 0.81 HTR7 (1.00) HTR2BHTR2AALDH1A1HTR7HTR1A
Disulergine SCHEMBL11408971 0.81 HTR7 (1.00) HTR2BHTR2AALDH1A1HTR7HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2118 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4378532-B1 COMPOUNDS AND METHODS FOR TREATING FIBROTIC PATHOLOGIES MAYO FOUND MEDICAL EDUCATION & RES (US) 2025-11-12 EP claimed
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS TESSELLATE THERAPEUTICS INC (US) 2025-09-25 US claimed
US-20250179086-A1 COMPOUNDS AND METHODS FOR TREATING FIBROTIC PATHOLOGIES MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2025-06-05 US claimed
EP-4547250-A1 METHODS AND COMPOSITIONS RELATING TO CONTROLLING PSYCHEDELIC EFFECTS WITH SEROTONIN RECEPTOR MODULATORS Terran Biosciences Inc. (US) 2025-05-07 EP claimed
US-20250049748-A1 ANALOGS OF 4-BROMO-2,5-DIMETHOXYPHENETHYLAMINE TERRAN BIOSCIENCES INC (US) 2025-02-13 US claimed
US-20240252463-A1 METHODS OF TREATING FIBROTIC PATHOLOGIES MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2024-08-01 US claimed
US-20240226110-A1 5-HT2C AGONIST FOR USE IN TREATING CONDITIONS ASSOCIATED WITH CENTRAL HYPOVENTILATION APNIMED, INC. (DELAWARE) 2024-07-11 US claimed
EP-3745862-B1 D1 DOPAMINE RECEPTOR AGONISTS FOR TREATING FIBROTIC PATHOLOGIES MAYO FOUND MEDICAL EDUCATION & RES (US) 2024-06-26 EP claimed
US-20240197681-A1 METHODS AND COMPOSITIONS RELATING TO PSYCHEDELICS AND SEROTONIN RECEPTOR MODULATORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-06-20 US claimed
EP-4378532-A2 COMPOUNDS AND METHODS FOR TREATING FIBROTIC PATHOLOGIES Mayo Foundation for Medical Education and Research (US) 2024-06-05 EP claimed
WO-1999065563-A1 ELECTRICALLY ASSISTED TRANSDERMAL METHOD AND APPARATUS FOR THE TREATMENT OF ERECTILE DYSFUNCTION GENETRONICS, INC. (US) 1999-12-23 WO claimed
WO-1998042331-A1 MEDIATION OF CIRCADIAN RHYTHMS LUMINIS PTY. LIMITED (AU) 1998-10-01 WO claimed
EP-0527835-B1 DOSAGE FORM TO DELIVER AN ANTIPARKINSON AGENT ALZA CORP (US) 1994-10-26 EP claimed
US-5221536-A Dosage form indicated for the management of abnormal posture, tremor and involuntary movement ALZA CORPORATION (US) 1993-06-22 US claimed
US-5192550-A Dosage form for treating central nervous system disorders ALZA CORPORATION (US) 1993-03-09 US claimed
US-5190763-A DOSAGE FORM INDICATED FOR THE MANAGEMENT OF ABNORMAL POSTURE, TREMOR AND INVOLUNTARY MOVEMENT ALZA CORPORATION (US) 1993-03-02 US claimed
EP-0527835-A1 DOSAGE FORM TO DELIVER AN ANTIPARKINSON AGENT. ALZA CORP (US) 1993-02-24 EP claimed
WO-1991016885-A1 DOSAGE FORM TO DELIVER AN ANTIPARKINSON AGENT ALZA CORPORATION (US) 1991-11-14 WO claimed
US-5057321-A Dosage form comprising drug and maltodextrin ALZA CORPORATION (US) 1991-10-15 US claimed
US-4225605-A Ergolene or ergoline compounds for treating congestive heart failure SANDOZ LTD. (CH) 1980-09-30 US claimed