Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 15/20 | 0.45 |
| ▸ | ATM | Q13315 | 4/20 | 0.45 |
| ▸ | ATR | Q13535 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | FECH | P22830 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | MELK | Q14680 | 1/20 | 0.39 |
| ▸ | MYLK3 | Q32MK0 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.39 |
| ▸ | TP53RK | Q96S44 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30012567 | 1.00 | MTOR (0.45) | MTORATMATRPIK3CATLR9 | |
| SCHEMBL30012314 | 0.90 | ATM (0.48) | MTORATMATRPIK3CATLR9 | |
| SCHEMBL29217588 | 0.90 | ATM (0.48) | MTORATMATRPIK3CATLR9 | |
| SCHEMBL30011984 | 0.89 | ATM (0.45) | MTORATMATRPIK3CATLR9 | |
| SCHEMBL29217613 | 0.89 | ATM (0.45) | MTORATMATRPIK3CATLR9 | |
| SCHEMBL30011050 | 0.85 | MTOR (0.41) | MTORATMATRPIK3CAPIK3CD | |
| SCHEMBL30839669 | 0.77 | TLR9 (0.37) | MTORATMATRPIK3CATLR9 | |
| SCHEMBL30011901 | 0.76 | ATM (0.44) | MTORATMATRPIK3CATLR9 | |
| SCHEMBL29217574 | 0.76 | ATM (0.44) | MTORATMATRPIK3CATLR9 | |
| SCHEMBL30011461 | 0.75 | ATM (0.42) | MTORATMATRPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114026097-B | Substituted pyrazoloquinazolinone compounds and uses thereof | 上海瑛派药业有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-114026097-A | Substituted pyrazoloquinazolinone compounds and uses thereof | 上海瑛派药业有限公司 | 2022-02-08 | — | — | CN | disclosed |