Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30162918 | 1.00 | GRM5 (0.39) | GRM5BACE1PRMT5WDR77HRH3 | |
| SCHEMBL22408092 | 0.88 | ROCK1 (0.39) | GRM5BACE1PRMT5WDR77ROCK1 | |
| SCHEMBL28980408 | 0.88 | ITGB3 (0.37) | GRM5BACE1PRMT5WDR77HRH3 | |
| SCHEMBL29896931 | 0.87 | KCNH2 (0.42) | GRM5PRMT5WDR77HRH3ROCK1 | |
| SCHEMBL15796700 | 0.87 | KCNH2 (0.42) | GRM5PRMT5WDR77HRH3ROCK1 | |
| SCHEMBL28988093 | 0.83 | ROCK1 (0.38) | BACE1ROCK1 | |
| SCHEMBL31642273 | 0.83 | SIK2 (0.39) | GRM5PRMT5WDR77HRH3ROCK1 | |
| SCHEMBL15796518 | 0.82 | BACE1 (0.41) | GRM5BACE1PRMT5WDR77ROCK1 | |
| SCHEMBL29896800 | 0.82 | BACE1 (0.41) | GRM5BACE1PRMT5WDR77ROCK1 | |
| SCHEMBL29421580 | 0.80 | GRM5 (0.47) | GRM5BACE1PRMT5WDR77ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118055926-A | ROCK2 inhibitors and uses thereof | 哈佛大学的校长及成员们 | 2024-05-17 | — | — | CN | disclosed |