Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 15/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 9/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2291 | 0.91 | LTB4R2 (0.35) | LTB4R2AGTR1AGTR2ABCB11GP6 | |
| SCHEMBL3104 | 0.84 | AGTR1 (0.50) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL8474813 | 0.83 | AGTR1 (0.41) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL6558886 | 0.83 | AGTR1 (0.38) | LTB4R2AGTR1AGTR2ABCB11GP6 | |
| Abitesartan SCHEMBL2527 | 0.83 | AGTR1 (0.51) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL2568 | 0.81 | AGTR1 (0.39) | LTB4R2AGTR1AGTR2ABCB11GP6 | |
| SCHEMBL9429949 | 0.80 | LTB4R2 (0.45) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL9429833 | 0.79 | LTB4R2 (0.46) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL9429691 | 0.79 | LTB4R2 (0.47) | LTB4R2AGTR1AGTR2ABCB11GP6 | |
| Abitesartan SCHEMBL8473295 | 0.79 | AGTR1 (0.47) | LTB4R2AGTR1AGTR2ABCB11GP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | claimed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |