SCHEMBL29220109

SCHEMBL29220109

O=C(O)C[C@@H](O)c1ccc(Cl)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABBR2 O75899 3/20 0.59
GABBR1 Q9UBS5 3/20 0.59
CYP2C9 P11712 3/20 0.59
KMT2A Q03164 3/20 0.59
LMNA P02545 2/20 0.59
CYP2D6 P10635 2/20 0.59
CYP2C19 P33261 2/20 0.59
MEN1 O00255 2/20 0.59
CYP3A4 P08684 1/20 0.59
ADORA3 P0DMS8 1/20 0.59
NFKB1 P19838 1/20 0.59
DRD3 P35462 1/20 0.59
BLM P54132 1/20 0.59
CYP1A2 P05177 1/20 0.59
THRB P10828 1/20 0.59
TSHR P16473 1/20 0.59
HSD17B10 Q99714 1/20 0.54
FFAR1 O14842 1/20 0.50
AOC3 Q16853 1/20 0.47
FNTA P49354 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1503961 1.00 GABBR2 (0.59) GABBR2GABBR1CYP2C9KMT2ALMNA
SCHEMBL3520190 0.83 GABBR2 (0.63) GABBR2GABBR1CYP2C9KMT2ALMNA
SCHEMBL3950248 0.82 AOC3 (0.50) GABBR2GABBR1CYP2C9KMT2ALMNA
SCHEMBL16897111 0.82 AOC3 (0.50) GABBR2GABBR1CYP2C9KMT2ALMNA
SCHEMBL27573301 0.82 AOC3 (0.50) GABBR2GABBR1CYP2C9KMT2ALMNA
SCHEMBL27573299 0.82 AOC3 (0.50) GABBR2GABBR1CYP2C9KMT2ALMNA
SCHEMBL5864212 0.81 TAAR1 (0.54) CYP2C9LMNACYP2D6CYP2C19CYP3A4
SCHEMBL4483465 0.81 TAAR1 (0.54) CYP2C9LMNACYP2D6CYP2C19CYP3A4
SCHEMBL4483463 0.81 TAAR1 (0.54) CYP2C9LMNACYP2D6CYP2C19CYP3A4
SCHEMBL391659 0.81 GABBR2 (0.79) GABBR2GABBR1CYP2C9KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118108598-A Method for synthesizing chiral beta-hydroxy carboxylic ester by catalysis of ruthenium complex 中国科学院大连化学物理研究所 2024-05-31 CN disclosed