Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753817 | 0.80 | MEN1 (0.58) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL424285 | 0.76 | HIF1A (0.59) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL2755865 | 0.76 | KDM4E (0.62) | MEN1KMT2AALDH1A1RAB9AHIF1A | |
| SCHEMBL9382808 | 0.76 | MEN1 (0.53) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL2796515 | 0.76 | TAAR1 (0.52) | KDM4E | |
| SCHEMBL7974996 | 0.75 | HIF1A (0.58) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL7974997 | 0.75 | HIF1A (0.58) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL424284 | 0.75 | HIF1A (0.58) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL31059181 | 0.75 | KDM4E (0.68) | ALDH1A1SMN1; SMN2HIF1AKDM4ETDP1 | |
| SCHEMBL31059180 | 0.75 | KDM4E (0.68) | ALDH1A1SMN1; SMN2HIF1AKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227233-A2 | IDO INHIBITORS | Newlink Genetics (US) | 2010-09-15 | — | — | EP | claimed |
| WO-2009073620-A2 | IDO INHIBITORS | NEWLINK GENETICS (US) | 2009-06-11 | — | — | WO | claimed |