Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 6/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 6/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | PRKCB | P05771 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCH | P24723 | 1/20 | 0.43 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29264315 | 0.85 | DDB1 (0.53) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL23538562 | 0.83 | DDB1 (0.55) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL31202060 | 0.83 | DDB1 (0.49) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL29223677 | 0.83 | DDB1 (0.49) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL29946867 | 0.82 | DDB1 (0.54) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL24320207 | 0.82 | HRH3 (0.58) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL31630962 | 0.82 | DDB1 (0.52) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL26684271 | 0.82 | SCN9A (0.56) | DDB1CRBNSCN9AKDM4EMAPT | |
| SCHEMBL31729273 | 0.81 | DDB1 (0.54) | DDB1CRBNSCN9AKDM4EMAPT | |
| SCHEMBL31451146 | 0.81 | SCN9A (0.46) | DDB1CRBNSCN9AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117858874-A | HPK1 degrading agents, compositions comprising the same, and methods of use thereof | 百放开曼有限公司 | 2024-04-09 | — | — | CN | disclosed |