Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK6 | Q00534 | 13/20 | 0.49 |
| ▸ | CCND1 | P24385 | 8/20 | 0.49 |
| ▸ | CDK4 | P11802 | 8/20 | 0.49 |
| ▸ | CCND3 | P30281 | 8/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.49 |
| ▸ | CDK2 | P24941 | 7/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.49 |
| ▸ | CDK9 | P50750 | 4/20 | 0.49 |
| ▸ | CDK7 | P50613 | 3/20 | 0.49 |
| ▸ | CCNH | P51946 | 3/20 | 0.49 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.49 |
| ▸ | PLK1 | P53350 | 7/20 | 0.48 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 5/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29226263 | 0.92 | PLK1 (0.51) | CDK6CCND1CDK4CCND3CCNA2 | |
| SCHEMBL29246493 | 0.89 | CDK6 (0.50) | CDK6CCND1CDK4CCND3CCNA2 | |
| SCHEMBL29246403 | 0.87 | CDK6 (0.48) | CDK6CCND1CDK4CCND3CCNA2 | |
| SCHEMBL30825131 | 0.87 | PLK1 (0.54) | CCNA2CDK2PLK1PLK3FLT3 | |
| SCHEMBL29226660 | 0.86 | PLK1 (0.43) | CCNA2CDK2PLK1PLK3FLT3 | |
| SCHEMBL29226647 | 0.86 | KDR (0.36) | CDK6CCND1CDK4CCND3CCNA2 | |
| SCHEMBL29226360 | 0.85 | PLK1 (0.41) | CCNA2CDK2PLK1PLK3FLT3 | |
| SCHEMBL29246384 | 0.85 | CDK6 (0.46) | CDK6CCND1CDK4CCND3CCNA2 | |
| SCHEMBL29226279 | 0.84 | PLK1 (0.51) | CDK6CCND1CCNA2CDK2PLK1 | |
| SCHEMBL29226349 | 0.84 | TNK2 (0.51) | CCNA2CDK2PLK1PLK3CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024051717-A1 | COMPOUND AS PLK1 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海深势唯思科技有限责任公司 | 2024-03-14 | — | — | WO | disclosed |
| CN-117658987-A | Compounds as PLK1 inhibitors, and preparation method and application thereof | 上海深势唯思科技有限责任公司 | 2024-03-08 | — | — | CN | disclosed |