Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK6 | Q00534 | 18/20 | 0.46 |
| ▸ | CDK4 | P11802 | 13/20 | 0.46 |
| ▸ | CCND1 | P24385 | 8/20 | 0.46 |
| ▸ | CCND3 | P30281 | 8/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.46 |
| ▸ | CDK2 | P24941 | 7/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.46 |
| ▸ | CDK9 | P50750 | 4/20 | 0.46 |
| ▸ | CDK7 | P50613 | 3/20 | 0.46 |
| ▸ | CCNH | P51946 | 3/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.46 |
| ▸ | PIM1 | P11309 | 5/20 | 0.42 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 3/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29246403 | 0.95 | CDK6 (0.48) | CDK6CDK4CCND1CCND3CCNA2 | |
| SCHEMBL29246689 | 0.93 | CCND1 (0.45) | CDK6CDK4CCND1CCND3CCNA2 | |
| SCHEMBL29246493 | 0.93 | CDK6 (0.50) | CDK6CDK4CCND1CCND3CCNA2 | |
| SCHEMBL29246530 | 0.89 | CCND1 (0.44) | CDK6CDK4CCND1CCND3CCNA2 | |
| SCHEMBL29246590 | 0.87 | CCND1 (0.46) | CDK6CDK4CCND1CCND3CCNA2 | |
| SCHEMBL29246474 | 0.86 | JAK2 (0.44) | CDK6CDK4CCND1CCND3CCNA2 | |
| SCHEMBL29226641 | 0.85 | CDK6 (0.49) | CDK6CDK4CCND1CCND3CCNA2 | |
| SCHEMBL29246568 | 0.85 | CDK6 (0.41) | CDK6CDK4CCND1CCND3CCNA2 | |
| SCHEMBL29246355 | 0.84 | JAK2 (0.39) | CDK6CDK4CCND1CCND3CCNA2 | |
| SCHEMBL29246339 | 0.84 | CDK6 (0.40) | CDK6CDK4CCND1CCND3CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118307521-A | Pyrimidine PLK1 inhibitor and preparation method and application thereof | 上海深势唯思科技有限责任公司 | 2024-07-09 | — | — | CN | disclosed |