Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5449603 | 0.91 | MEN1 (0.49) | KMT2AMAPTALOX15HSD17B10SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2927668 | 0.91 | MEN1 (0.48) | KMT2AMAPTALOX15HSD17B10SMN1; SMN2 | |
| SCHEMBL6503870 | 0.91 | FGFR1 (0.45) | KMT2ASMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL2928661 | 0.90 | KMT2A (0.38) | KMT2AMAPTALDH1A1ALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL2927706 | 0.90 | FGFR1 (0.44) | KMT2ASMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL3903873 | 0.89 | FGFR1 (0.42) | KMT2AMAPTALDH1A1ALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL5894517 | 0.89 | KMT2A (0.38) | KMT2AMAPTALDH1A1ALOX15HSD17B10 | |
| SCHEMBL2921040 | 0.88 | FGFR1 (0.40) | KMT2AMAPTALDH1A1ALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL2929385 | 0.88 | KMT2A (0.38) | KMT2AMAPTALDH1A1ALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL2923186 | 0.88 | FGFR1 (0.42) | KMT2AMAPTALDH1A1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644376-B1 | PYRROLO 3,4-c PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-09-08 | — | — | EP | disclosed |
| EP-1644376-A1 | PYRROLO 3,4-c PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005005427-A1 | PYRROLO[3,4-c]PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2005-01-20 | — | — | WO | disclosed |