Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 14/20 | 0.66 |
| ▸ | PRSS2 | P07478 | 14/20 | 0.66 |
| ▸ | PRSS3 | P35030 | 14/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911159 | 0.87 | PRSS1 (0.85) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2107314 | 0.83 | PRSS1 (0.75) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2108898 | 0.82 | PRSS1 (0.76) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2108654 | 0.81 | PRSS1 (0.55) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2919117 | 0.81 | PRSS1 (0.85) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2916087 | 0.80 | PRSS1 (0.84) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2919978 | 0.80 | PRSS1 (1.00) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL8050294 | 0.79 | PRSS1 (0.61) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2109951 | 0.79 | PRSS1 (0.52) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2921545 | 0.78 | PRSS1 (0.79) | PRSS1PRSS2PRSS3MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2224803-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009067202-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-05-28 | — | — | WO | disclosed |