Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 14/20 | 0.61 |
| ▸ | PRSS2 | P07478 | 14/20 | 0.61 |
| ▸ | PRSS3 | P35030 | 14/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660313 | 0.87 | PRSS1 (0.46) | PRSS1PRSS2PRSS3NPSR1TACR1 | |
| SCHEMBL8051630 | 0.85 | PRSS1 (0.68) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL8054572 | 0.84 | PRSS1 (0.69) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL8033994 | 0.83 | PRSS1 (0.51) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2911159 | 0.83 | PRSS1 (0.85) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL8051350 | 0.80 | PRSS1 (0.47) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2922733 | 0.79 | PRSS1 (0.66) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2919117 | 0.77 | PRSS1 (0.85) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2916087 | 0.76 | PRSS1 (0.84) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL2919978 | 0.76 | PRSS1 (1.00) | PRSS1PRSS2PRSS3MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8536189-B2 | Spiropiperidines for use as tryptase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2013-09-17 | — | — | US | disclosed |
| WO-2009067202-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-05-28 | — | — | WO | disclosed |