Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 8/20 | 0.56 |
| ▸ | JAK1 | P23458 | 5/20 | 0.56 |
| ▸ | CDK7 | P50613 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | MERTK | Q12866 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29232107 | 0.85 | AXL (0.51) | TYK2JAK1CDK7CDK9AXL | |
| SCHEMBL29883088 | 0.84 | JAK1 (0.53) | TYK2JAK1CDK7CDK9AXL | |
| SCHEMBL29232009 | 0.84 | JAK1 (0.53) | TYK2JAK1CDK7CDK9AXL | |
| SCHEMBL29232106 | 0.82 | TYK2 (0.55) | TYK2JAK1CDK7CDK9AXL | |
| SCHEMBL29883000 | 0.81 | TYK2 (0.60) | TYK2JAK1 | |
| SCHEMBL30636208 | 0.77 | TYK2 (0.72) | TYK2JAK1 | |
| SCHEMBL16712862 | 0.77 | TYK2 (0.72) | TYK2JAK1 | |
| SCHEMBL27294015 | 0.76 | TYK2 (0.59) | TYK2JAK1CDK9AXLMAPK8 | |
| SCHEMBL15713486 | 0.76 | TYK2 (0.71) | TYK2JAK1 | |
| SCHEMBL27417191 | 0.76 | JAK3 (0.49) | TYK2JAK1CDK7CDK9AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197196-B | TYK2 inhibitor and application thereof | 扬子江药业集团有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-115197196-A | TYK2 inhibitor and application thereof | 扬子江药业集团有限公司 | 2022-10-18 | — | — | CN | disclosed |