Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 14/20 | 0.55 |
| ▸ | JAK1 | P23458 | 10/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | MERTK | Q12866 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29232107 | 0.85 | AXL (0.51) | TYK2JAK1CYP2C19CDK7CDK9 | |
| SCHEMBL29232006 | 0.82 | TYK2 (0.56) | TYK2JAK1CDK7CDK9AXL | |
| SCHEMBL29882777 | 0.81 | TYK2 (0.48) | TYK2JAK1CYP2C19SYKKCNH2 | |
| SCHEMBL30751500 | 0.80 | TYK2 (0.53) | TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL30751557 | 0.80 | TYK2 (0.54) | TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL29883074 | 0.80 | TYK2 (0.52) | TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL30751501 | 0.79 | TYK2 (0.53) | TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL30751558 | 0.79 | TYK2 (0.53) | TYK2JAK1CYP2C19KCNH2 | |
| Parent Of Bms-986202 SCHEMBL18102142 | 0.76 | TYK2 (0.89) | TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL22313887 | 0.75 | TYK2 (0.55) | TYK2JAK1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197196-B | TYK2 inhibitor and application thereof | 扬子江药业集团有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-115197196-A | TYK2 inhibitor and application thereof | 扬子江药业集团有限公司 | 2022-10-18 | — | — | CN | disclosed |