SCHEMBL29235271

SCHEMBL29235271

COc1cc(/C=C/C(=O)NN)ccc1O

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 7/20 0.71
CYP2D6 P10635 3/20 0.71
APP P05067 3/20 0.71
CYP2C9 P11712 2/20 0.71
TSHR P16473 2/20 0.71
HSD17B10 Q99714 2/20 0.71
CYP1A2 P05177 2/20 0.71
ALOX5 P09917 2/20 0.71
NFKB1 P19838 2/20 0.71
HSD11B1 P28845 2/20 0.71
STAT3 P40763 2/20 0.71
NFKB2 Q00653 2/20 0.71
RELA Q04206 2/20 0.71
NFE2L2 Q16236 2/20 0.71
HDAC3 O15379 2/20 0.71
TYR P14679 2/20 0.71
HDAC1 Q13547 2/20 0.71
HDAC2 Q92769 2/20 0.71
HDAC6 Q9UBN7 2/20 0.71
KDM4E B2RXH2 2/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29204551 1.00 KDM1A (0.71) KDM1ACYP2D6APPCYP2C9TSHR
SCHEMBL459772 0.88 BCHE (0.66) KDM1AAPPKDM4EMAPTMAOA
SCHEMBL459773 0.88 BCHE (0.66) KDM1AAPPKDM4EMAPTMAOA
SCHEMBL15052623 0.88 NFE2L2 (0.69) CYP2C9HSD17B10CYP1A2NFKB1NFE2L2
SCHEMBL15052622 0.88 NFE2L2 (0.69) CYP2C9HSD17B10CYP1A2NFKB1NFE2L2
SCHEMBL10726474 0.87 KDM1A (0.73) KDM1ACYP2D6APPCYP2C9TSHR
SCHEMBL14880218 0.87 HDAC3 (0.89) KDM1ACYP2D6APPCYP2C9TSHR
Curcumin SCHEMBL28636637 0.84 APP (0.94) KDM1ACYP2D6APPCYP2C9TSHR
Methyl Cis-Ferulate SCHEMBL510492 0.83 EPHX2 (1.00) KDM1ACYP2D6APPCYP2C9TSHR
SCHEMBL2951016 0.83 CYP2D6 (0.77) KDM1ACYP2D6APPCYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117886807-A Ferulic acid derivative containing 1,3, 4-oxadiazole and trifluoromethyl pyrimidine 贵阳学院 2024-04-16 CN disclosed