Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.62 |
| ▸ | FLT3 | P36888 | 6/20 | 0.62 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 7/20 | 0.43 |
| ▸ | JAK1 | P23458 | 6/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29236031 | 0.94 | JAK2 (0.56) | JAK2FLT3PARP1JAK3JAK1 | |
| SCHEMBL29235922 | 0.93 | JAK2 (0.54) | JAK2FLT3PARP1JAK3JAK1 | |
| SCHEMBL29235842 | 0.93 | JAK2 (0.60) | JAK2FLT3HDAC1HDAC6JAK3 | |
| SCHEMBL29235899 | 0.87 | JAK2 (0.47) | JAK2FLT3HDAC1HDAC6JAK3 | |
| SCHEMBL29235968 | 0.85 | JAK2 (0.85) | JAK2FLT3PARP1JAK3JAK1 | |
| SCHEMBL29236074 | 0.82 | JAK2 (0.48) | JAK2FLT3HDAC1HDAC6JAK3 | |
| SCHEMBL29235914 | 0.81 | JAK2 (0.52) | JAK2FLT3HDAC1HDAC6JAK3 | |
| SCHEMBL30839092 | 0.81 | FLT3 (0.61) | JAK2FLT3PARP1CDK4CCND1 | |
| SCHEMBL29236023 | 0.79 | JAK2 (0.78) | JAK2FLT3JAK3JAK1CDK4 | |
| SCHEMBL29235929 | 0.79 | JAK2 (0.84) | JAK2FLT3JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118005609-A | 2-Aminopyrimidine compound and application thereof | 沈阳药科大学 | 2024-05-10 | — | — | CN | claimed |
| CN-118005609-A | 2-Aminopyrimidine compound and application thereof | 沈阳药科大学 | 2024-05-10 | — | — | CN | disclosed |