Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 5/20 | 0.36 |
| ▸ | SLC8A1 | P32418 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2878585 | 0.91 | IRAK1 (0.39) | IRAK1IRAK4SCN9AADORA2AADORA1 | |
| SCHEMBL388891 | 0.90 | SCN9A (0.42) | IRAK1IRAK4SCN9AADORA2AADORA1 | |
| SCHEMBL391325 | 0.90 | BRAF (0.41) | IRAK1IRAK4SCN9AADORA2AADORA1 | |
| SCHEMBL391330 | 0.87 | IRAK1 (0.41) | IRAK1IRAK4SCN9AADORA2AADORA1 | |
| SCHEMBL387938 | 0.85 | SCN9A (0.38) | IRAK1IRAK4SCN9AADORA2AADORA1 | |
| SCHEMBL388901 | 0.84 | IRAK1 (0.38) | IRAK1IRAK4SCN9AADORA2AADORA1 | |
| SCHEMBL2873640 | 0.84 | IRAK1 (0.39) | IRAK1IRAK4SCN9AADORA2AADORA1 | |
| SCHEMBL2879156 | 0.84 | BRAF (0.45) | IRAK1IRAK4SCN9AADORA2AADORA1 | |
| SCHEMBL392407 | 0.83 | BRAF (0.38) | IRAK1IRAK4SCN9AADORA2AADORA1 | |
| SCHEMBL2986069 | 0.83 | SCN9A (0.40) | IRAK1IRAK4SCN9AADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125793-B1 | IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2010-09-01 | — | — | EP | disclosed |