Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20584483 | 1.00 | HSD17B10 (0.39) | HSD17B10HDAC8SMN1; SMN2SPHK1NR1H2 | |
| SCHEMBL20446517 | 1.00 | HSD17B10 (0.39) | HSD17B10HDAC8SMN1; SMN2SPHK1NR1H2 | |
| SCHEMBL22123735 | 1.00 | HSD17B10 (0.39) | HSD17B10HDAC8SMN1; SMN2SPHK1NR1H2 | |
| SCHEMBL29239179 | 1.00 | HSD17B10 (0.39) | HSD17B10HDAC8SMN1; SMN2SPHK1NR1H2 | |
| SCHEMBL22123778 | 1.00 | HSD17B10 (0.39) | HSD17B10HDAC8SMN1; SMN2SPHK1NR1H2 | |
| SCHEMBL16774511 | 0.89 | HSD17B10 (0.39) | HSD17B10HDAC8SMN1; SMN2SPHK1NR1H2 | |
| SCHEMBL16774512 | 0.87 | SMN1; SMN2 (0.39) | HSD17B10HDAC8SMN1; SMN2SPHK1NR1H2 | |
| SCHEMBL2380326 | 0.86 | IMPDH2 (0.39) | HSD17B10HDAC8SMN1; SMN2SPHK1NR1H2 | |
| SCHEMBL2380328 | 0.86 | IMPDH2 (0.39) | HSD17B10HDAC8SMN1; SMN2SPHK1NR1H2 | |
| SCHEMBL5512140 | 0.84 | HSD17B10 (0.36) | HSD17B10HDAC8SMN1; SMN2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114981259-B | Novel heterocyclic compound | 豪夫迈·罗氏有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-114981259-A | Novel heterocyclic compound | 豪夫迈·罗氏有限公司 | 2022-08-30 | — | — | CN | disclosed |