SCHEMBL29240602

SCHEMBL29240602

Clc1ccc(Oc2ccc(C3(CBr)OCCO3)c(Cl)c2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.37
MAOA P21397 2/20 0.37
PDE4A P27815 1/20 0.35
PDE4B Q07343 1/20 0.35
PDE4C Q08493 1/20 0.35
PDE4D Q08499 1/20 0.35
LMNA P02545 2/20 0.34
CYP3A4 P08684 1/20 0.34
THRB P10828 1/20 0.34
ALDH1A1 P00352 1/20 0.33
SIGMAR1 Q99720 2/20 0.32
ADAMTS5 Q9UNA0 1/20 0.32
HTR2A P28223 4/20 0.32
SLC6A4 P31645 4/20 0.32
KCNH2 Q12809 4/20 0.32
LTA4H P09960 1/20 0.32
PTGS2 P35354 1/20 0.32
SOS1 Q07889 1/20 0.31
ABCB11 O95342 1/20 0.31
MMP1 P03956 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20031368 0.86 CYP3A4 (0.38) MAOBMAOAPDE4APDE4BPDE4C
SCHEMBL11452099 0.84 SLC6A4 (0.41) CYP3A4THRBALDH1A1SLC6A4
SCHEMBL30380036 0.84 SLC6A4 (0.41) CYP3A4THRBALDH1A1SLC6A4
SCHEMBL20000648 0.83 AR (0.46) MAOBMAOAPDE4APDE4BPDE4C
SCHEMBL11451906 0.83 GRIN1 (0.41) SIGMAR1HTR2ASLC6A4KCNH2
SCHEMBL29240604 0.82 CYP3A4 (0.51) LMNACYP3A4THRBALDH1A1SIGMAR1
SCHEMBL28037605 0.82 CYP3A4 (0.39) LMNACYP3A4THRBALDH1A1SIGMAR1
SCHEMBL29240597 0.79 CYP3A4 (0.52) LMNACYP3A4THRBALDH1A1SIGMAR1
SCHEMBL29240599 0.78 MAOA (0.39) MAOBMAOAPDE4APDE4BPDE4C
SCHEMBL21632262 0.77 CYP3A4 (0.38) LMNACYP3A4THRBALDH1A1SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118108587-A Method for preparing phenylate ketone bromide 江苏扬农化工股份有限公司 2024-05-31 CN disclosed