SCHEMBL29240959

SCHEMBL29240959

O[C@H](CCCl)c1ccc(Br)o1

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.33
HPGD P15428 4/20 0.33
MAPT P10636 2/20 0.33
THRB P10828 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
TAS1R3 Q7RTX0 1/20 0.33
TAS1R1 Q7RTX1 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.31
KMT2A Q03164 2/20 0.30
NPSR1 Q6W5P4 1/20 0.30
TSHR P16473 1/20 0.30
MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29240964 1.00 ALDH1A1 (0.33) ALDH1A1HPGDMAPTTHRBTDP1
SCHEMBL14752505 0.67
SCHEMBL1979222 0.67 IGF1R (0.42) KMT2AMEN1
SCHEMBL22660732 0.65 KMT2A (0.44) ALDH1A1MAPTTDP1SMN1; SMN2KMT2A
SCHEMBL1933837 0.65 KMT2A (0.44) ALDH1A1MAPTTDP1SMN1; SMN2KMT2A
SCHEMBL22660731 0.65 KMT2A (0.44) ALDH1A1MAPTTDP1SMN1; SMN2KMT2A
SCHEMBL6498646 0.64 CYP3A4 (0.31) KMT2A
SCHEMBL6050469 0.64 CYP3A4 (0.31) KMT2A
SCHEMBL29240989 0.63 GSK3B (0.39)
SCHEMBL29240988 0.63 GSK3B (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107840845-B Novel use of amine compound 上海璃道医药科技有限公司 2024-07-02 CN disclosed