Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 15/20 | 0.84 |
| ▸ | BRAF | P15056 | 8/20 | 0.84 |
| ▸ | KDR | P35968 | 6/20 | 0.84 |
| ▸ | RET | P07949 | 3/20 | 0.84 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.84 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.84 |
| ▸ | ABL1 | P00519 | 2/20 | 0.84 |
| ▸ | HTR1A | P08908 | 2/20 | 0.84 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.84 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.84 |
| ▸ | KIT | P10721 | 2/20 | 0.84 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.84 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.84 |
| ▸ | FLT1 | P17948 | 2/20 | 0.84 |
| ▸ | MAOA | P21397 | 2/20 | 0.84 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.84 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.84 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.84 |
| ▸ | TTK | P33981 | 2/20 | 0.84 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16628076 | 0.94 | RAF1 (0.81) | RAF1BRAFKDRRETRIPK2 | |
| SCHEMBL10199708 | 0.92 | RAF1 (0.74) | RAF1BRAFKDRRETRIPK2 | |
| SCHEMBL6030121 | 0.91 | RAF1 (0.89) | RAF1BRAFKDRRETRIPK2 | |
| Sorafenib SCHEMBL8218 | 0.91 | RAF1 (1.00) | RAF1BRAFKDRRETRIPK2 | |
| Sorafenib SCHEMBL14739751 | 0.91 | RAF1 (1.00) | RAF1BRAFKDRRETRIPK2 | |
| Sorafenib SCHEMBL29349634 | 0.91 | RAF1 (1.00) | RAF1BRAFKDRRETRIPK2 | |
| Sorafenib SCHEMBL1533976 | 0.90 | RAF1 (0.98) | RAF1BRAFKDRRETRIPK2 | |
| Sorafenib SCHEMBL1533982 | 0.90 | RAF1 (0.98) | RAF1BRAFKDRRETRIPK2 | |
| Sorafenib SCHEMBL1896610 | 0.90 | RAF1 (0.98) | RAF1BRAFKDRRETRIPK2 | |
| Sorafenib SCHEMBL18863920 | 0.90 | RAF1 (0.98) | RAF1BRAFKDRRETRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121102253-A | Pharmaceutical composition containing saikosaponin B2 and sorafenib and application thereof | 浙江中医药大学 | 2025-12-12 | — | — | CN | disclosed |
| CN-119925616-A | CD20 therapy, CD22 therapy and combination therapy with CD19 Chimeric Antigen Receptor (CAR) expressing cells | 诺华股份有限公司 | 2025-05-06 | — | — | CN | disclosed |
| CN-118234496-A | Improved treatment of advanced/metastatic cancers with checkpoint inhibitor resistance or drug resistance susceptibility | 海南先声再明医药股份有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-117866991-A | Chimeric antigen receptor for the treatment of cancer | 诺华股份有限公司 | 2024-04-12 | — | — | CN | disclosed |
| CN-110225927-B | Chimeric antigen receptor for the treatment of cancer | 诺华股份有限公司 | 2024-01-12 | — | — | CN | disclosed |