Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL575096 | 0.97 | — | — | |
| Ethyne SCHEMBL19712788 | 0.90 | — | — | |
| Ethylene SCHEMBL7892170 | 0.90 | — | — | |
| Ethyl Chloride SCHEMBL28559362 | 0.88 | — | — | |
| Ethylene Glycol SCHEMBL11322064 | 0.88 | TSHR (0.35) | TSHR | |
| Butane SCHEMBL22228988 | 0.85 | ALDH1A1 (0.35) | TSHR | |
| SCHEMBL29001766 | 0.83 | TSHR (0.32) | TSHR | |
| Acetonitrile SCHEMBL28332086 | 0.81 | — | — | |
| Propene SCHEMBL27994316 | 0.81 | — | — | |
| SCHEMBL8812944 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114008058-B | Prodrugs of CDK inhibitors for the treatment of cancer | 润佳（苏州）医药科技有限公司 | 2024-07-05 | — | — | CN | disclosed |