SCHEMBL29246749

SCHEMBL29246749

CCOC(=O)c1cc(C(C)=O)c(O)c2ccccc12

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.57
POLB P06746 2/20 0.57
MEN1 O00255 1/20 0.57
NSD2 O96028 1/20 0.57
MAPT P10636 1/20 0.57
KMT2A Q03164 1/20 0.57
MCL1 Q07820 1/20 0.57
TSHR P16473 2/20 0.54
GAA P10253 3/20 0.50
ALDH1A1 P00352 3/20 0.50
HPGD P15428 3/20 0.50
NPC1 O15118 1/20 0.49
CCR6 P51684 1/20 0.48
CASP3 P42574 1/20 0.48
CASP7 P55210 1/20 0.48
CASP9 P55211 1/20 0.48
CDC25B P30305 2/20 0.48
HSD17B10 Q99714 3/20 0.47
CA12 O43570 2/20 0.46
CA1 P00915 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28416763 0.82 TSHR (0.63) KDM4EPOLBTSHRGAAALDH1A1
SCHEMBL19737311 0.82 ALDH1A1 (0.59) KDM4EMEN1MAPTKMT2ATSHR
SCHEMBL10749448 0.81 MAPT (0.61) KDM4EPOLBMEN1NSD2MAPT
SCHEMBL7848703 0.79 TSHR (0.63) KDM4EPOLBTSHRGAAALDH1A1
SCHEMBL2569253 0.78 TSHR (0.73) KDM4EMEN1MAPTKMT2ATSHR
SCHEMBL29671336 0.78 TSHR (0.73) KDM4EMEN1MAPTKMT2ATSHR
SCHEMBL27933355 0.78 CCR6 (0.53) KDM4EMEN1MAPTKMT2ATSHR
SCHEMBL9750199 0.77 PDE3B (0.56) KDM4ETSHR
SCHEMBL3945626 0.77 TSHR (0.84) KDM4EPOLBTSHRGAAALDH1A1
SCHEMBL14141531 0.76 TSHR (0.59) KDM4EMEN1KMT2ATSHRGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118307411-A Preparation method of 2-acyl naphthol compound 西北工业大学 2024-07-09 CN disclosed