Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK2 | P53671 | 11/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.44 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30372519 | 1.00 | LIMK2 (0.53) | LIMK2MAP4K4HDAC1ROCK2ROCK1 | |
| SCHEMBL29247286 | 1.00 | LIMK2 (0.53) | LIMK2MAP4K4HDAC1ROCK2ROCK1 | |
| SCHEMBL30295362 | 0.89 | LIMK2 (0.57) | LIMK2MAP4K4ROCK2ROCK1LIMK1 | |
| SCHEMBL29247120 | 0.86 | LRRK2 (0.59) | LIMK2MAP4K4HDAC1ROCK2ROCK1 | |
| SCHEMBL30295262 | 0.86 | LRRK2 (0.59) | LIMK2MAP4K4HDAC1ROCK2ROCK1 | |
| SCHEMBL29247127 | 0.86 | LRRK2 (0.59) | LIMK2MAP4K4HDAC1ROCK2ROCK1 | |
| SCHEMBL29247486 | 0.86 | KIT (0.55) | ROCK2ROCK1LIMK1LRRK2CDC42BPB | |
| SCHEMBL30372597 | 0.86 | KIT (0.55) | ROCK2ROCK1LIMK1LRRK2CDC42BPB | |
| SCHEMBL3807817 | 0.84 | LIMK2 (0.65) | LIMK2MAP4K4ROCK2ROCK1LIMK1 | |
| SCHEMBL3648782 | 0.84 | LIMK2 (0.65) | LIMK2MAP4K4ROCK2ROCK1LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118317963-A | TRPML modulators, compositions thereof, and methods of use | 卡拉韦治疗公司 | 2024-07-09 | — | — | CN | disclosed |