Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 5/20 | 0.55 |
| ▸ | BTK | Q06187 | 2/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.47 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | AKT1S1 | Q96B36 | 1/20 | 0.47 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | STK3 | Q13188 | 3/20 | 0.44 |
| ▸ | CDC7 | O00311 | 2/20 | 0.44 |
| ▸ | MARK3 | P27448 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30372597 | 1.00 | KIT (0.55) | KITBTKLRRK2ROCK2ROCK1 | |
| SCHEMBL29247560 | 0.87 | KIT (0.45) | KITBTKROCK2ROCK1CDC42BPB | |
| SCHEMBL29247293 | 0.86 | LIMK2 (0.53) | LRRK2ROCK2ROCK1CDC42BPBLIMK1 | |
| SCHEMBL29247726 | 0.86 | BTK (0.51) | KITBTKROCK2ROCK1CDC42BPB | |
| SCHEMBL30372519 | 0.86 | LIMK2 (0.53) | LRRK2ROCK2ROCK1CDC42BPBLIMK1 | |
| SCHEMBL30295210 | 0.86 | BTK (0.51) | KITBTKROCK2ROCK1CDC42BPB | |
| SCHEMBL29247286 | 0.86 | LIMK2 (0.53) | LRRK2ROCK2ROCK1CDC42BPBLIMK1 | |
| SCHEMBL29247122 | 0.86 | BTK (0.51) | KITBTKROCK2ROCK1CDC42BPB | |
| SCHEMBL16637074 | 0.85 | LRRK2 (0.61) | KITBTKLRRK2AKT1AKT1S1 | |
| SCHEMBL30295133 | 0.85 | LRRK2 (0.61) | KITBTKLRRK2AKT1AKT1S1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118317963-A | TRPML modulators, compositions thereof, and methods of use | 卡拉韦治疗公司 | 2024-07-09 | — | — | CN | disclosed |