Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 10/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29247649 | 1.00 | GPR119 (0.45) | GPR119MAP4K4LIMK2ROCK2LIMK1 | |
| SCHEMBL30372808 | 1.00 | GPR119 (0.45) | GPR119MAP4K4LIMK2ROCK2LIMK1 | |
| SCHEMBL30372628 | 0.93 | LIMK2 (0.44) | GPR119MAP4K4LIMK2ROCK2LIMK1 | |
| SCHEMBL30294934 | 0.90 | GPR119 (0.45) | GPR119MAP4K4LIMK2HDAC1NR1H2 | |
| SCHEMBL29247091 | 0.90 | GPR119 (0.45) | GPR119MAP4K4LIMK2HDAC1NR1H2 | |
| SCHEMBL29247096 | 0.90 | GPR119 (0.45) | GPR119MAP4K4LIMK2HDAC1NR1H2 | |
| SCHEMBL29247773 | 0.89 | GPR119 (0.44) | GPR119MAP4K4LIMK2HDAC1NR1H2 | |
| SCHEMBL29247230 | 0.89 | GPR119 (0.44) | GPR119MAP4K4LIMK2HDAC1NR1H2 | |
| SCHEMBL30295286 | 0.89 | GPR119 (0.44) | GPR119MAP4K4LIMK2HDAC1NR1H2 | |
| SCHEMBL30372822 | 0.89 | GPR119 (0.44) | GPR119MAP4K4LIMK2HDAC1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118317963-A | TRPML modulators, compositions thereof, and methods of use | 卡拉韦治疗公司 | 2024-07-09 | — | — | CN | disclosed |