Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 4/20 | 0.62 |
| ▸ | MMP2 | P08253 | 2/20 | 0.62 |
| ▸ | MMP12 | P39900 | 1/20 | 0.62 |
| ▸ | MMP1 | P03956 | 3/20 | 0.49 |
| ▸ | MMP13 | P45452 | 3/20 | 0.49 |
| ▸ | MMP3 | P08254 | 2/20 | 0.49 |
| ▸ | MMP7 | P09237 | 2/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1655664 | 0.90 | MMP9 (0.73) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL8271936 | 0.89 | MMP9 (0.57) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1655808 | 0.89 | MMP9 (0.57) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL2925250 | 0.87 | MMP9 (0.61) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL5546935 | 0.87 | MMP9 (0.61) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL5531373 | 0.86 | MMP9 (0.60) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1655569 | 0.86 | MMP9 (0.60) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1655568 | 0.85 | MMP9 (0.67) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL5532545 | 0.85 | MMP9 (0.67) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1656113 | 0.83 | MMP9 (0.61) | MMP9MMP2MMP12MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768979-B1 | OCTAHYDROPYRROLO[2, 3, C]PYRIDINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | MERCK SERONO SA (CH) | 2010-09-29 | — | — | EP | claimed |