Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | FLT4 | P35916 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 2/20 | 0.38 |
| ▸ | CCNH | P51946 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22097895 | 1.00 | JAK2 (0.43) | JAK2JAK3JAK1KDRFLT4 | |
| SCHEMBL28603765 | 0.91 | PAK1 (0.49) | JAK2JAK3JAK1KDRFLT4 | |
| SCHEMBL28600666 | 0.89 | KDR (0.44) | JAK2JAK3JAK1KDRFLT4 | |
| SCHEMBL22090054 | 0.89 | KDR (0.44) | JAK2JAK3JAK1KDRFLT4 | |
| SCHEMBL29941888 | 0.89 | KDR (0.44) | JAK2JAK3JAK1KDRFLT4 | |
| SCHEMBL22098067 | 0.84 | JAK2 (0.43) | JAK2JAK3JAK1FLT4MAPK1 | |
| SCHEMBL24853255 | 0.84 | MAPK1 (0.49) | JAK2JAK3JAK1KDRFLT4 | |
| SCHEMBL28612291 | 0.84 | MAPK1 (0.49) | JAK2JAK3JAK1KDRFLT4 | |
| SCHEMBL29942003 | 0.84 | MAPK1 (0.49) | JAK2JAK3JAK1KDRFLT4 | |
| SCHEMBL27450355 | 0.83 | KDR (0.40) | JAK2JAK3JAK1KDRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |