Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22090054 | 1.00 | KDR (0.44) | KDRFLT4JAK2JAK3JAK1 | |
| SCHEMBL29941888 | 1.00 | KDR (0.44) | KDRFLT4JAK2JAK3JAK1 | |
| SCHEMBL22089901 | 0.91 | JAK2 (0.47) | JAK2JAK3JAK1MAPK1AURKA | |
| SCHEMBL28607945 | 0.91 | JAK2 (0.47) | JAK2JAK3JAK1MAPK1AURKA | |
| SCHEMBL29941633 | 0.91 | JAK2 (0.47) | JAK2JAK3JAK1MAPK1AURKA | |
| SCHEMBL22097895 | 0.89 | JAK2 (0.43) | KDRFLT4JAK2JAK3JAK1 | |
| SCHEMBL29249077 | 0.89 | JAK2 (0.43) | KDRFLT4JAK2JAK3JAK1 | |
| SCHEMBL28602196 | 0.84 | AURKA (0.44) | FLT4JAK2JAK3JAK1AURKA | |
| SCHEMBL22089934 | 0.84 | AURKA (0.44) | FLT4JAK2JAK3JAK1AURKA | |
| SCHEMBL22097850 | 0.83 | MAPK1 (0.47) | KDRFLT4JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | claimed |
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | disclosed |