SCHEMBL29249356

SCHEMBL29249356

O=C(O)CN(CC(=O)O)c1ccc(NC(=O)c2ccc(-c3ccccc3)cc2)cc1N(CC(=O)O)CC(=O)O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 2/20 0.56
PTPN1 P18031 3/20 0.54
DEGS1 O15121 1/20 0.54
TRPV1 Q8NER1 2/20 0.53
PARP1 P09874 1/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
MEN1 O00255 2/20 0.51
MAPT P10636 2/20 0.51
KMT2A Q03164 2/20 0.51
KDM4E B2RXH2 1/20 0.51
LMNA P02545 1/20 0.51
CYP19A1 P11511 1/20 0.49
HDAC1 Q13547 1/20 0.49
POLB P06746 2/20 0.49
STAT3 P40763 1/20 0.49
PSMD14 O00487 1/20 0.48
RECQL P46063 1/20 0.48
CACNA1B Q00975 1/20 0.48
APBA1 Q02410 1/20 0.48
CTDSP1 Q9GZU7 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29249357 0.92 KCNK3 (0.54) PTPN1SMN1; SMN2MEN1MAPTKMT2A
SCHEMBL29249362 0.82 NPC1 (0.58) SMN1; SMN2MEN1MAPTKMT2AKDM4E
SCHEMBL29249372 0.77 KCNK3 (0.62) SMN1; SMN2MEN1KMT2AKDM4EPOLB
SCHEMBL29249359 0.75 KCNK3 (0.60) SMN1; SMN2MEN1MAPTKMT2AKDM4E
SCHEMBL2026664 0.73 PTPN1 (0.96) NR1H4PTPN1DEGS1TRPV1PARP1
SCHEMBL10136221 0.73 PTPN1 (0.96) NR1H4PTPN1DEGS1TRPV1SMN1; SMN2
SCHEMBL14160276 0.73 PTPN1 (0.96) NR1H4PTPN1DEGS1TRPV1SMN1; SMN2
SCHEMBL2834990 0.72 PTPN1 (0.74) NR1H4PTPN1DEGS1TRPV1SMN1; SMN2
SCHEMBL23226675 0.72 HDAC1 (0.79) NR1H4PTPN1DEGS1TRPV1SMN1; SMN2
SCHEMBL30116663 0.72 HDAC1 (0.79) NR1H4PTPN1DEGS1TRPV1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324653-A Compound, metal compound, preparation method and application thereof, contrast agent and imaging method 四川大学 2024-07-12 CN disclosed