SCHEMBL29249359

SCHEMBL29249359

COc1ccccc1C(=O)Nc1ccc(N(CC(=O)O)CC(=O)O)c(N(CC(=O)O)CC(=O)O)c1

nearest known ligand 0.60

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 6/20 0.60
KCNK9 Q9NPC2 6/20 0.60
MAPK1 P28482 2/20 0.58
MAPT P10636 6/20 0.55
RAB9A P51151 4/20 0.55
ALDH1A1 P00352 2/20 0.55
POLB P06746 3/20 0.54
KMT2A Q03164 3/20 0.54
TP53 P04637 4/20 0.53
SMN1; SMN2 Q16637 3/20 0.53
KDM4E B2RXH2 2/20 0.53
NPC1 O15118 3/20 0.53
TSHR P16473 2/20 0.53
MEN1 O00255 1/20 0.53
RXFP1 Q9HBX9 1/20 0.53
BRPF1 P55201 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29249357 0.79 KCNK3 (0.54) KCNK3KCNK9MAPK1MAPTRAB9A
SCHEMBL29249362 0.78 NPC1 (0.58) KCNK3KCNK9MAPTRAB9AALDH1A1
SCHEMBL29249372 0.78 KCNK3 (0.62) KCNK3KCNK9MAPK1RAB9AALDH1A1
SCHEMBL2362772 0.76 KMT2A (0.82) KCNK3KCNK9MAPK1MAPTRAB9A
SCHEMBL11594247 0.76 KCNK3 (0.71) KCNK3KCNK9MAPK1MAPTRAB9A
SCHEMBL29249356 0.75 NR1H4 (0.56) MAPTPOLBKMT2ASMN1; SMN2KDM4E
SCHEMBL2060705 0.75 NR1H4 (0.73) KCNK3KCNK9MAPK1MAPTRAB9A
SCHEMBL11749630 0.74 KCNK3 (0.56) KCNK3KCNK9MAPK1MAPTRAB9A
SCHEMBL11789635 0.74 KCNK3 (0.68) KCNK3KCNK9MAPK1MAPTRAB9A
SCHEMBL2721612 0.73 MAPT (0.73) KCNK3KCNK9MAPK1MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324653-A Compound, metal compound, preparation method and application thereof, contrast agent and imaging method 四川大学 2024-07-12 CN disclosed