Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 2/20 | 0.42 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | KDM4B | O94953 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 4/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11793035 | 0.90 | PLAT (0.37) | PSMB8PSMB9PSMB5HRH4NPC1 | |
| SCHEMBL28842193 | 0.81 | PSMB8 (0.42) | PSMB8PSMB9PSMB5HRH4NPC1 | |
| SCHEMBL23132293 | 0.81 | PSMB8 (0.41) | PSMB8PSMB9LMNATP53SMN1; SMN2 | |
| SCHEMBL7278970 | 0.79 | NPC1 (0.53) | PSMB8PSMB9PSMB5HRH4NPC1 | |
| SCHEMBL9386057 | 0.79 | PSMB8 (0.41) | PSMB8PSMB9PSMB5HRH4NPC1 | |
| SCHEMBL26847648 | 0.78 | HRH4 (0.41) | PSMB8PSMB9PSMB5HRH4NPC1 | |
| SCHEMBL4432408 | 0.77 | NPC1 (0.54) | PSMB8PSMB9PSMB5HRH4NPC1 | |
| SCHEMBL25646885 | 0.75 | TLR8 (0.41) | PSMB8PSMB9NR1I2KDM4BCHRM1 | |
| SCHEMBL14369649 | 0.74 | HSD11B1 (0.38) | PSMB8PSMB9PSMB5HRH4NPC1 | |
| SCHEMBL5223113 | 0.73 | NPC1 (0.50) | PSMB8PSMB9PSMB5HRH4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114401964-B | Compound with BRD4 inhibitory activity, preparation method and application thereof | 上海海和药物研究开发股份有限公司 | 2024-10-01 | — | — | CN | disclosed |
| CN-118271364-A | 3, 5-Dialkyl-4- (disubstituted phosphino) -1-alkyl-1H-pyrazole and preparation method and application thereof | 香港理工大学深圳研究院 | 2024-07-02 | — | — | CN | disclosed |