SCHEMBL29249786

SCHEMBL29249786

C=CC(=O)N(C)c1ccccc1C#Cc1ccc(C)cc1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.43
CA2 P00918 1/20 0.43
CA9 Q16790 1/20 0.43
FFAR1 O14842 12/20 0.39
BTK Q06187 3/20 0.37
CHRM2 P08172 1/20 0.36
S1PR1 P21453 1/20 0.36
FPR1 P21462 1/20 0.36
FPR3 P25089 1/20 0.36
GPR183 P32249 1/20 0.36
APLNR P35414 1/20 0.36
FFAR4 Q5NUL3 1/20 0.36
GPR65 Q8IYL9 1/20 0.36
VCP P55072 1/20 0.36
ACACB O00763 1/20 0.35
EGLN1 Q9GZT9 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29249809 0.90 NPC1 (0.43) CA12CA2CA9FFAR1BTK
SCHEMBL29249778 0.88 APP (0.37) FFAR1BTKCHRM2S1PR1FPR1
SCHEMBL29249801 0.88 LMNA (0.43) FFAR1BTKCHRM2S1PR1FPR1
SCHEMBL29249830 0.86 BCL2A1 (0.46) FFAR1ACACBNPC1RAB9A
SCHEMBL29249803 0.86 ACACB (0.38) FFAR1BTKCHRM2S1PR1FPR1
SCHEMBL29249794 0.85 PTPN1 (0.38) FFAR1BTKACACB
SCHEMBL29249773 0.84 FFAR1 (0.38) FFAR1FFAR4VCPACACBEGLN1
SCHEMBL29249865 0.81 BCL2A1 (0.41) FFAR1BTK
SCHEMBL29249785 0.81 PTGDR2 (0.42) BTK
SCHEMBL29249832 0.81 MEN1 (0.35) BTKNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324695-A Method for selectively preparing quinoline-2-ketone or 3, 4-dihydro-quinoline-2-ketone compound under regulation of photocatalyst 浙江工业大学 2024-07-12 CN disclosed