Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 14/20 | 0.55 |
| ▸ | CCND1 | P24385 | 7/20 | 0.55 |
| ▸ | CDK6 | Q00534 | 14/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.53 |
| ▸ | CDK2 | P24941 | 6/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | CCND3 | P30281 | 11/20 | 0.51 |
| ▸ | CCND2 | P30279 | 3/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 5/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.51 |
| ▸ | CDK9 | P50750 | 3/20 | 0.51 |
| ▸ | CDK7 | P50613 | 2/20 | 0.51 |
| ▸ | CCNH | P51946 | 2/20 | 0.51 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30237663 | 1.00 | CDK4 (0.55) | CDK4CCND1CDK6CCNA2CDK2 | |
| SCHEMBL30237143 | 0.92 | CDK6 (0.59) | CDK4CCND1CDK6CCNA2CDK2 | |
| SCHEMBL30237278 | 0.92 | CDK4 (0.61) | CDK4CCND1CDK6CCNA2CDK2 | |
| SCHEMBL30236752 | 0.92 | CDK4 (0.63) | CDK4CCND1CDK6CCNA2CDK2 | |
| SCHEMBL29250049 | 0.92 | CDK4 (0.61) | CDK4CCND1CDK6CCNA2CDK2 | |
| SCHEMBL29250151 | 0.92 | CDK6 (0.59) | CDK4CCND1CDK6CCNA2CDK2 | |
| SCHEMBL29250060 | 0.92 | CDK4 (0.63) | CDK4CCND1CDK6CCNA2CDK2 | |
| SCHEMBL30947450 | 0.90 | CDK6 (0.51) | CDK4CCND1CDK6CCNA2CDK2 | |
| SCHEMBL30237425 | 0.90 | CDK6 (0.59) | CDK4CCND1CDK6CCNA2CDK2 | |
| SCHEMBL29250062 | 0.90 | CDK6 (0.59) | CDK4CCND1CDK6CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115703760-B | 2, 4-Disubstituted pyrimidine cyclin dependent kinase enzyme inhibitor and preparation method and application thereof | 山东大学 | 2024-05-31 | — | — | CN | disclosed |