Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 14/20 | 0.63 |
| ▸ | CDK6 | Q00534 | 13/20 | 0.63 |
| ▸ | CCND3 | P30281 | 5/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.59 |
| ▸ | CDK1 | P06493 | 2/20 | 0.59 |
| ▸ | CCND1 | P24385 | 11/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.54 |
| ▸ | CSF1R | P07333 | 2/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | CCNK | O75909 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | CCND2 | P30279 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29250060 | 1.00 | CDK4 (0.63) | CDK4CDK6CCND3CCNA2CDK1 | |
| SCHEMBL30237663 | 0.92 | CDK4 (0.55) | CDK4CDK6CCND3CCNA2CDK1 | |
| SCHEMBL29250080 | 0.92 | CDK4 (0.55) | CDK4CDK6CCND3CCNA2CDK1 | |
| SCHEMBL29250049 | 0.90 | CDK4 (0.61) | CDK4CDK6CCND3CCNA2CDK1 | |
| SCHEMBL30237278 | 0.90 | CDK4 (0.61) | CDK4CDK6CCND3CCNA2CDK1 | |
| SCHEMBL30237143 | 0.90 | CDK6 (0.59) | CDK4CDK6CCND3CCNA2CDK1 | |
| SCHEMBL29250151 | 0.90 | CDK6 (0.59) | CDK4CDK6CCND3CCNA2CDK1 | |
| SCHEMBL30237425 | 0.88 | CDK6 (0.59) | CDK4CDK6CCND3CCNA2CDK1 | |
| SCHEMBL30947450 | 0.88 | CDK6 (0.51) | CDK4CDK6CCND3CCNA2CDK1 | |
| SCHEMBL29250062 | 0.88 | CDK6 (0.59) | CDK4CDK6CCND3CCNA2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115703760-B | 2, 4-Disubstituted pyrimidine cyclin dependent kinase enzyme inhibitor and preparation method and application thereof | 山东大学 | 2024-05-31 | — | — | CN | disclosed |
| CN-115703760-A | 2,4-disubstituted pyrimidines cyclin dependent kinase inhibitor and preparation method and application thereof | 山东大学 | 2023-02-17 | — | — | CN | disclosed |