Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 20/20 | 0.54 |
| ▸ | MMP2 | P08253 | 4/20 | 0.54 |
| ▸ | MMP13 | P45452 | 3/20 | 0.54 |
| ▸ | MMP14 | P50281 | 1/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.52 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23745336 | 1.00 | ADAMTS5 (0.54) | ADAMTS5MMP2MMP13MMP14ADAM17 | |
| SCHEMBL29835144 | 1.00 | ADAMTS5 (0.54) | ADAMTS5MMP2MMP13MMP14ADAM17 | |
| SCHEMBL29835174 | 1.00 | ADAMTS5 (0.54) | ADAMTS5MMP2MMP13MMP14ADAM17 | |
| SCHEMBL29250240 | 1.00 | ADAMTS5 (0.54) | ADAMTS5MMP2MMP13MMP14ADAM17 | |
| SCHEMBL23745213 | 1.00 | ADAMTS5 (0.54) | ADAMTS5MMP2MMP13MMP14ADAM17 | |
| SCHEMBL23745335 | 1.00 | ADAMTS5 (0.54) | ADAMTS5MMP2MMP13MMP14ADAM17 | |
| SCHEMBL29835131 | 1.00 | ADAMTS5 (0.54) | ADAMTS5MMP2MMP13MMP14ADAM17 | |
| SCHEMBL23745293 | 0.91 | ADAMTS5 (0.48) | ADAMTS5MMP2MMP13MMP14ADAM17 | |
| SCHEMBL23745289 | 0.91 | ADAMTS5 (0.48) | ADAMTS5MMP2MMP13MMP14ADAM17 | |
| SCHEMBL23727429 | 0.91 | ADAMTS5 (0.48) | ADAMTS5MMP2MMP13MMP14ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115052596-B | ADAMTS inhibitor, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-115052596-A | ADAMTS inhibitor, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-09-13 | — | — | CN | disclosed |