Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 18/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.55 |
| ▸ | MMP2 | P08253 | 5/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.53 |
| ▸ | MMP13 | P45452 | 2/20 | 0.53 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP12 | P39900 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29250247 | 1.00 | ADAMTS5 (0.55) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL23745340 | 0.91 | ADAMTS5 (0.59) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL29835156 | 0.91 | ADAMTS5 (0.59) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL29250244 | 0.91 | ADAMTS5 (0.59) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL31121194 | 0.86 | ADAMTS5 (0.69) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL23745413 | 0.86 | ADAMTS5 (0.69) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL23727712 | 0.85 | ADAMTS5 (0.66) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL23745412 | 0.85 | ADAMTS5 (0.65) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL23727713 | 0.85 | ADAMTS5 (0.66) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 | |
| SCHEMBL29835195 | 0.85 | ADAMTS5 (0.66) | ADAMTS5ADAM17MMP2ADAMTS4MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115052596-B | ADAMTS inhibitor, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2024-06-14 | — | — | CN | disclosed |