Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 6/20 | 0.56 |
| ▸ | CDK19 | Q9BWU1 | 4/20 | 0.56 |
| ▸ | JAK3 | P52333 | 5/20 | 0.52 |
| ▸ | SYK | P43405 | 3/20 | 0.52 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | CDC7 | O00311 | 2/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | PAK4 | O96013 | 2/20 | 0.52 |
| ▸ | PIM1 | P11309 | 2/20 | 0.52 |
| ▸ | PRKACA | P17612 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.52 |
| ▸ | CLK2 | P49760 | 2/20 | 0.52 |
| ▸ | GSK3A | P49840 | 2/20 | 0.52 |
| ▸ | CDK7 | P50613 | 2/20 | 0.52 |
| ▸ | CDK9 | P50750 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30584592 | 1.00 | ALK (0.56) | ALKCDK19JAK3SYKGSK3B | |
| SCHEMBL29250994 | 0.85 | EGFR (0.46) | ALKCDK19JAK3JAK2EGFR | |
| SCHEMBL30584611 | 0.83 | JAK3 (0.47) | ALKCDK19JAK3SYKGSK3B | |
| SCHEMBL29250639 | 0.83 | JAK3 (0.47) | ALKCDK19JAK3SYKGSK3B | |
| SCHEMBL29250694 | 0.83 | JAK3 (0.42) | ALKCDK19JAK3SYKGSK3B | |
| SCHEMBL24392935 | 0.81 | EGFR (0.51) | ALKCDK19JAK3SYKGSK3B | |
| SCHEMBL29537972 | 0.81 | EGFR (0.51) | ALKCDK19JAK3SYKGSK3B | |
| SCHEMBL29250652 | 0.81 | CDK2 (0.52) | ALKCDK19JAK3SYKGSK3B | |
| SCHEMBL30584604 | 0.80 | JAK3 (0.42) | ALKCDK19JAK3SYKGSK3B | |
| SCHEMBL29250667 | 0.80 | JAK3 (0.42) | ALKCDK19JAK3SYKGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116685583-A | Pyrimidine compounds, compositions and pharmaceutical uses thereof | 缆图药品公司 | 2023-09-01 | — | — | CN | disclosed |