Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | CDK9 | P50750 | 2/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 4/20 | 0.48 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | ULK1 | O75385 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29508200 | 0.84 | CDK2 (0.51) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29250627 | 0.82 | CCNT1 (0.49) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29537008 | 0.82 | CCNT1 (0.49) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29065154 | 0.82 | ALK (0.68) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL30584592 | 0.81 | ALK (0.56) | CDK2CDK9ALKCDK19EGFR | |
| SCHEMBL29250568 | 0.81 | ALK (0.56) | CDK2CDK9ALKCDK19EGFR | |
| SCHEMBL24392935 | 0.78 | EGFR (0.51) | CDK2CDK9ALKCDK19EGFR | |
| SCHEMBL29537972 | 0.78 | EGFR (0.51) | CDK2CDK9ALKCDK19EGFR | |
| SCHEMBL16513292 | 0.76 | EGFR (0.61) | EGFRJAK3JAK2MAP3K7MAPK1 | |
| SCHEMBL21358342 | 0.74 | PIN1 (0.57) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237418-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | Blueprint Medicines Corporation (US) | 2023-09-06 | — | — | EP | disclosed |
| CN-116685583-A | Pyrimidine compounds, compositions and pharmaceutical uses thereof | 缆图药品公司 | 2023-09-01 | — | — | CN | disclosed |
| WO-2022094354-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |