Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 13/20 | 0.64 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8197373 | 0.88 | ERN1 (0.51) | ERN1CA1CA2ALDH1A1TSHR | |
| SCHEMBL8233989 | 0.83 | ERN1 (0.46) | ERN1ALDH1A1 | |
| SCHEMBL20799740 | 0.79 | TTR (0.41) | ERN1TTRCA1CA2ALDH1A1 | |
| SCHEMBL29424939 | 0.78 | ERN1 (1.00) | ERN1TTRPIM1 | |
| SCHEMBL1527177 | 0.78 | ERN1 (1.00) | ERN1TTRPIM1 | |
| SCHEMBL2788053 | 0.78 | ERN1 (0.78) | ERN1PIM1CA1CA2ALDH1A1 | |
| SCHEMBL14876912 | 0.78 | ERN1 (0.47) | ERN1ALDH1A1TSHR | |
| SCHEMBL29957335 | 0.78 | ERN1 (0.78) | ERN1PIM1CA1CA2ALDH1A1 | |
| SCHEMBL24170744 | 0.78 | TTR (0.39) | ERN1TTRCA1CA2 | |
| SCHEMBL5646596 | 0.77 | ERN1 (0.56) | ERN1TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231619-B1 | INHIBITORS OF STEAROYL-COA DESATURASE | HOFFMANN LA ROCHE (CH) | 2014-11-26 | — | — | EP | disclosed |
| CN-101896473-B | Inhibitors of stearoyl-coa desaturase | HOFFMANN LA ROCHE | 2012-07-25 | — | — | CN | disclosed |
| CN-101896473-A | Inhibitors of stearoyl-coa desaturase | HOFFMANN LA ROCHE | 2010-11-24 | — | — | CN | disclosed |
| EP-2231619-A1 | INHIBITORS OF STEAROYL-COA DESATURASE | F. Hoffmann-La Roche AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| US-7652013-B2 | Inhibitors of stearoyl-CoA desaturase | HOFFMAN-LA ROCHE INC. (US) | 2010-01-26 | — | — | US | disclosed |
| WO-2009074487-A1 | INHIBITORS OF STEAROYL-COA DESATURASE | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-18 | — | — | WO | disclosed |
| US-20090149466-A1 | INHIBITORS OF STEAROYL-COA DESATURASE | GILLESPIE PAUL | 2009-06-11 | — | — | US | disclosed |
| US-5795560-A | Targeting protein-diagnostic/therapeutic agent conjugates having Schiff base linkages | NEORX CORPORATION (US) | 1998-08-18 | — | — | US | disclosed |
| US-5633351-A | Targeting protein-diagnostic/therapeutic agent conjugates having Schiff base linkages | NEORX CORPORATION (US) | 1997-05-27 | — | — | US | disclosed |
| US-5521290-A | REACTION OF MALEIMIDE GROUPS OF BIFUNCTIONAL LINKING COMPOUNDS WITH MOLECULES TO BE LINKED, THEN REACTING REMAINING ALDEHYDE AND HYDRAZIDE GROUPS OF LINKING COMPOUNDS | NEORX CORPORATION (US) | 1996-05-28 | — | — | US | disclosed |
| EP-0434765-B1 | TARGETING SUBSTANCE-DIAGNOSTIC/THERAPEUTIC AGENT CONJUGATES HAVING SCHIFF BASE LINKAGES | NEORX CORP (US) | 1995-11-08 | — | — | EP | disclosed |
| US-5349063-A | Radiolabled diamines | ALBERTA CANCER BOARD (CA) | 1994-09-20 | — | — | US | disclosed |
| EP-0434765-A4 | TARGETING SUBSTANCE-DIAGNOSTIC/THERAPEUTIC AGENT CONJUGATES HAVING SCHIFF BASE LINKAGES | — | 1992-06-03 | — | — | EP | disclosed |
| US-5066789-A | Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages | NEORX CORPORATION (US) | 1991-11-19 | — | — | US | disclosed |
| EP-0434765-A1 | TARGETING SUBSTANCE-DIAGNOSTIC/THERAPEUTIC AGENT CONJUGATES HAVING SCHIFF BASE LINKAGES. | NEORX CORP (US) | 1991-07-03 | — | — | EP | disclosed |
| WO-1990003401-A1 | TARGETING SUBSTANCE-DIAGNOSTIC/THERAPEUTIC AGENT CONJUGATES HAVING SCHIFF BASE LINKAGES | NEORX CORPORATION (US) | 1990-04-05 | — | — | WO | disclosed |
| US-4430319-A | DIAGNOSIS, ISOTOPE EXCHANGING, CONTAINERS, SODIUM PHOSPHATE BUFFERS | STATE UNIVERSITY OF NEW YORK (US) | 1984-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149466-A1 | INHIBITORS OF STEAROYL-COA DESATURASE | SCD, SCD5, FADS2 | ERN1 2423/4885TTR 3299/4885PIM1 3674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.