Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 20/20 | 0.68 |
| ▸ | PPARA | Q07869 | 14/20 | 0.66 |
| ▸ | PPARD | Q03181 | 7/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7914288 | 1.00 | PPARG (0.68) | PPARGPPARAPPARD | |
| SCHEMBL6203537 | 0.90 | PPARG (0.67) | PPARGPPARAPPARD | |
| SCHEMBL4026006 | 0.88 | PPARG (0.65) | PPARGPPARAPPARD | |
| SCHEMBL7897370 | 0.88 | PPARG (0.67) | PPARGPPARAPPARD | |
| SCHEMBL7903513 | 0.86 | PPARG (0.68) | PPARGPPARAPPARD | |
| SCHEMBL4026004 | 0.85 | PPARG (0.61) | PPARGPPARAPPARD | |
| SCHEMBL7897417 | 0.85 | PPARG (0.70) | PPARGPPARAPPARD | |
| SCHEMBL7904793 | 0.84 | PPARG (0.75) | PPARGPPARAPPARD | |
| SCHEMBL2926077 | 0.84 | PPARG (0.70) | PPARGPPARAPPARD | |
| SCHEMBL2926075 | 0.84 | PPARG (0.70) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1757596-B1 | TYROSINE DERIVATIVES SUBSTITUTED BY N-PHENYLACRYLOYL AS AGONISTS OF HPPAR ALPHA AND HPPAR GAMA | BEIJING MOLECULE SCIENCE AND T (CN) | 2010-09-29 | — | — | EP | disclosed |
| US-7781468-B2 | Tyrosine derivatives substituted by N-arylacryloyl as agonists of hPPAR alpha and/or hPPAR gamma | Beijing Molecule Science Technology Co., Ltd. (CN) | 2010-08-24 | — | — | US | disclosed |
| US-7544687-B2 | Substituted α-piperazinyl phenylpropionic acid derivatives as hPPAR α and/or hPPAR γ agonists | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD (CN) | 2009-06-09 | — | — | US | disclosed |
| US-20080300286-A1 | Tyrosine Derivatives Substituted By N-Arylacryloyl as Agonists of Hppar Alpha and/or Hppar Gamma | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD (CN) | 2008-12-04 | — | — | US | disclosed |
| US-20070259883-A1 | Substitued A-Piperazingly Phenylpropionic Acid Derivatives As Hppar Alpha And/Or Hppar Gamma Agonists | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD. (CN) | 2007-11-08 | — | — | US | disclosed |
| EP-1757596-A1 | TYROSINE DERIVATIVES SUBSTITUTED BY N-PHENYLACRYLOYL AS AGONISTS OF HPPAR ALPHA AND HPPAR GAMA | Beijing Molecule Science and Technology Co., Ltd. (CN) | 2007-02-28 | — | — | EP | disclosed |
| EP-0888317-B1 | SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA | GLAXO GROUP LTD (GB) | 2001-09-12 | — | — | EP | disclosed |
| EP-0888317-A1 | SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA | GLAXO GROUP LIMITED (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997031907-A1 | SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA | GLAXO GROUP LIMITED (GB) | 1997-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259883-A1 | Substitued A-Piperazingly Phenylpropionic Acid Derivatives As Hppar Alpha And/Or Hppar Gamma Agonists | GPR119, PPARG, PPARA | PPARG 2/4885PPARA 3/4885PPARD 11/4885 |
| US-20080300286-A1 | Tyrosine Derivatives Substituted By N-Arylacryloyl as Agonists of Hppar Alpha and/or Hppar Gamma | GPR119, MTTP, GLP1R | PPARG 215/4885PPARA 216/4885PPARD 330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.