Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.44 |
| ▸ | INSR | P06213 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24352065 | 0.89 | EGFR (0.45) | EGFRINSRIGF1RALKBRD4 | |
| SCHEMBL24206738 | 0.84 | EGFR (0.52) | EGFRINSRALKBRD4MAPK9 | |
| SCHEMBL27031685 | 0.82 | EGFR (0.45) | EGFRINSRIGF1RALKBRD4 | |
| SCHEMBL29257368 | 0.82 | ALK (0.53) | EGFRALKCRBN | |
| SCHEMBL29257329 | 0.82 | EGFR (0.42) | EGFRINSRIGF1RALKBRD4 | |
| SCHEMBL29257351 | 0.81 | EGFR (0.57) | EGFRINSRIGF1RALKMAPK9 | |
| SCHEMBL29257364 | 0.80 | EGFR (0.56) | EGFRINSRIGF1RALKMAPK9 | |
| SCHEMBL29257383 | 0.79 | EGFR (0.42) | EGFRINSRIGF1RALKBRD4 | |
| SCHEMBL29257335 | 0.79 | ALK (0.48) | EGFRALKMAPK9MAPK10CRBN | |
| SCHEMBL24351539 | 0.78 | EGFR (0.55) | EGFRIGF1RALKBRD4CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116745280-A | Bifunctional compounds for degrading EGFR and related methods of use | 百济神州有限公司 | 2023-09-12 | — | — | CN | disclosed |