Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 5/20 | 0.53 |
| ▸ | PLK4 | O00444 | 5/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 6/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29257335 | 0.92 | ALK (0.48) | ALKPLK4CRBNPTK2EGFR | |
| SCHEMBL29257358 | 0.90 | ALK (0.48) | ALKPLK4CRBNPTK2EGFR | |
| SCHEMBL29257352 | 0.90 | ALK (0.48) | ALKPLK4CRBNPTK2EGFR | |
| SCHEMBL29257393 | 0.90 | ALK (0.48) | ALKPLK4CRBNPTK2EGFR | |
| SCHEMBL24352306 | 0.90 | ALK (0.53) | ALKPLK4CRBNBTKPTK2 | |
| SCHEMBL29257336 | 0.89 | ALK (0.61) | ALKCRBNPTK2EGFR | |
| SCHEMBL24351867 | 0.85 | ALK (0.47) | ALKPLK4CRBNBTKPTK2 | |
| SCHEMBL24351643 | 0.84 | CRBN (0.48) | ALKPLK4CRBNBTKPTK2 | |
| SCHEMBL29257341 | 0.83 | ALK (0.57) | ALKPLK4CRBNBTKPTK2 | |
| SCHEMBL29257346 | 0.83 | ALK (0.46) | ALKCRBNPTK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116745280-A | Bifunctional compounds for degrading EGFR and related methods of use | 百济神州有限公司 | 2023-09-12 | — | — | CN | disclosed |