Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29402362 | 0.90 | AKR1C3 (0.61) | ALDH1A1GAAMAPTNPC1RAB9A | |
| Benzene SCHEMBL27600962 | 0.90 | AKR1C3 (0.61) | ALDH1A1GAAMAPTNPC1RAB9A | |
| SCHEMBL9451511 | 0.90 | AKR1C3 (0.61) | ALDH1A1GAAMAPTNPC1RAB9A | |
| SCHEMBL236 | 0.90 | AKR1C3 (0.61) | ALDH1A1GAAMAPTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL27617106 | 0.88 | AKR1C3 (0.59) | ALDH1A1GAAMAPTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL28594496 | 0.88 | AKR1C3 (0.59) | ALDH1A1GAAMAPTNPC1RAB9A | |
| Benzophenone SCHEMBL28045477 | 0.88 | ALDH1A1 (0.61) | ALDH1A1GAAMAPTNPC1RAB9A | |
| SCHEMBL23534173 | 0.86 | AKR1C3 (0.63) | ALDH1A1GAAMAPTNPC1RAB9A | |
| O-Tolylamine SCHEMBL28857494 | 0.84 | MAPT (0.67) | ALDH1A1GAAMAPTNPC1RAB9A | |
| 2-Benzoylbenzoic Acid SCHEMBL15641067 | 0.83 | AKR1C3 (0.77) | ALDH1A1GAAMAPTAKR1C3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118178405-A | Application of mebendazole in preparing medicament for preventing or treating hepatic fibrosis | 中国药科大学 | 2024-06-14 | — | — | CN | disclosed |