Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.46 |
| ▸ | SMO | Q99835 | 15/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2925961 | 0.87 | MAPK14 (0.46) | MAPK14SMO | |
| SCHEMBL243560 | 0.84 | MAPK14 (0.49) | MAPK14SMO | |
| SCHEMBL243469 | 0.75 | MAPK14 (0.50) | MAPK14SMO | |
| Bromide SCHEMBL2928112 | 0.74 | MAPK14 (0.52) | MAPK14SMO | |
| SCHEMBL243467 | 0.73 | MAPK14 (0.50) | MAPK14SMO | |
| SCHEMBL2901891 | 0.71 | CHRNB2 (0.39) | MAPK14SMOALOX5CACNA1HCACNA1B | |
| SCHEMBL241948 | 0.69 | MAPK14 (0.53) | MAPK14SMO | |
| SCHEMBL245085 | 0.69 | MAPK14 (0.52) | MAPK14SMO | |
| SCHEMBL242756 | 0.68 | MAPK14 (0.52) | MAPK14SMO | |
| SCHEMBL244168 | 0.68 | MAPK14 (0.52) | MAPK14SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699766-B1 | AMIDE DERIVATIVES BEARING A CYCLOPROPYLAMINOACARBONYL SUBSTITUENT USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-11 | — | — | EP | disclosed |